March 5, 2011 – According to a report led by the Agency for Healthcare Research and Quality – part of the U.S. Department of Health and Human Services, the two most commonly prescribed classes of blood pressure-lowering medications angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) perform equally well in regulating high blood pressure. The report analyzed published results from 61 studies.
Funded by the AHRQ and completed by the Agency’s Duke University Evidence-based Practice Center in Durham, N.C., the study targeted both the benefits and disadvantages of ACEIs and ARBs. The conclusion drawn was that both classes of drugs control blood pressure effectively by stimulating the production of a hormone with a key role in regulating blood pressure. The AHRQ-funded study did not measure the performance of other blood pressure treatments such as beta-blockers or diuretics.
The ACEIs analyzed were benazepril (sold as Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik). The ARBs analyzed were candesartan cilexetil (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan medoxomil (Benicar), telmisartan (Micardis), and valsartan (Diovan).
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