Mark Thiede of Pfizer will give a presentation entitled “Inference by Interference: Controlling MSC Differentiation with RNAi†at the 4th International Stem Cell Research & Therapeutics, Apr 17-18, 2008 in Boston, MA.
Dr. Thiede will discuss how human adult stem cells such as bone marrow-derived mesenchymal stem cells (MSCs), the primary source of progenitors for tissue maintenance, can differentiate into adipocytes, osteocytes and chondrocytes in vitro. Understanding the key regulatory pathways of MSC proliferation and their lineage commitment is critical to the success of targeting drug therapies for regenerative medicine. RNAi technologies provide valuable tools with which to assess the functional consequences of the “knock down†of expression of target gene products. Undifferentiated and differentiated MSCs are being exposed to RNAi libraries that target drugable gene products (i.e receptors/enzymes) to identify gene products critical to MSC differentiation and the subsequent function of these differentiated cell types. Dr. Thiede will also discuss experimental approaches and observations.
The conference also features presentations from other leading organizations such as FDA, Geron, Joint Committee on Health Care Financing (by Senator Richard Moore), Merck, MIT, Novartis, Pfizer, Sangamo BioSciences, Sanofi Aventis, Stemagen, UCSB, University of Van Amsterdam, Whitehead Institute, and many more. The full agenda is available online at www.gtcbio.com.
GTCbio’s 4th Stem Cell Research & Therapeutics will take place on April 17-18, 2008 in Boston, MA and will cover Stem Cell Biology, Adult Stem Cells, Embryonic Stem Cells, Differentiation of Stem Cells, Epigenomics & Reprogramming of Stem Cells, Regenerative Medicine & Therapeutics, Stem Cell Imaging, Regulatory Aspects & Funding Opportunities, Cancer Stem Cells, and Stem Cell Applications in Drug Discovery.
For more information including a detailed agenda, exhibitor opportunities and registration information visit http://gtcbio.com/userAgenda.aspx?id=120
ABOUT GTCbio
GTCbio organizes conferences specifically for the biomedical and biopharmaceutical industries. Our goal is to facilitate the exchange of biopharmaceutical and biomedical intelligence between industry leaders, academic and government organizations, and the financial community.
GTCbio is a subsidiary of Global Technology Community, LLC, a privately held company founded in 2002.
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